Y-box Protein-1 Regulates the Expression of Collagen I in Hepatic Progenitor Cells via PDGFR-β/ERK/p90RSK Signalling

Figure 3

YB-1 regulates the synthesis of ECM proteins. (a) YB-1 knockdown promoted the mRNA expression of Col1a1, Col4a1, laminin, and TIMP-1, but suppressed the expression of MMP13. (b) Western blot assays provided evidence that YB-1 knockdown enhanced collagen I expression in HPCs. (c) CDE-injured mouse liver sections were stained with CK-19 and collagen I, and the results showed that collagen I can be expressed by a number of single dispersed CK-19-positive cells, which represented a subpopulation of HPCs.

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