Mesenchymal Stem Cells Promote Metastasis of Lung Cancer Cells by Downregulating Systemic Antitumor Immune Response

Figure 2

MSC treatment reduces influx of DCs, macrophages, and CD4+ T cells, in the metastatic model of lung cancer, and altered their cytokine profile. Total numbers of (a) CD45+, (b) CD45+ F4/80+, (c) CD45+ CD11c+ CD11b+, and CD11c+ TNF-α+ cells in the lungs of control, LLC1, and LLC1 + MSC-treated mice at the 28th day of the experiment. (d) Total number and representative flow cytometry dot plots of CD4+, TNF-α-, and IL-17-producing CD4+ cells at the 28th day of the experiment. (e) Total numbers of lung-infiltrating CD4+ IL-10+ cells at the 28th day of the experiment. Values are mean ± SEM (). , .

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