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| Human blood derivatives | Not human origin |
| Human serum (HS) | Human platelet lysate (hPL) | Human umbilical cord serum (hUCS) | Human plasma fractions (supplement for cell culture (SCC)) | Chemically defined media (CD) |
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| Advantages |
| No ethical problems | No ethical problems | No ethical problems | No ethical problems | No ethical problems |
| No risk of xenogenic compound transmission | No risk of xenogenic compound transmission | No risk of xenogenic compound transmission | No risk of xenogenic compound transmission | No risk of xenogenic compound transmission |
| Easy and inexpensive procedure | Contains high level of GF | Easy and inexpensive procedure | GMP compliant: compatible with pharmaceutical grade advanced therapies | No risk of transmission of human diseases |
| | | Contains high level of GF and proteins (transferrin, albumin, and fibronectin) | Little batch to batch variability (derived from an industrial plasma pool constituted from over 1000 donations) | |
| | | Easy-available allogenic source | Provides cell growth and attachment factors | |
| | | | Lyophilized: convenient for transport and storage | |
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| Disadvantages |
| Variability between individual donations | Variability between individual donations | Variability between individual donations | Ongoing: further investigation will help to a better characterization | Cell specific |
| Possibility of transmission of human diseases | Possibility of transmission of human diseases | Possibility of transmission of human diseases | | Ill-defined because it lacks of information provided by the companies |
| Low availability in terms of amount of donation | Low availability in terms of amount of donation | Low availability in terms of amount of donation | | Development may be expensive and time consuming |
| Discrepancy of results in allogenic settings | Not well defined composition in terms of GF content | | | Cell-adaptation may be necessary |
| Quality in autologous settings may not be ideal | Quite laborious and expensive procedure | | | |
| Often requires the addition of cytokines and GF | | | | |
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