Mitochondrial Heterogeneity: Evaluating Mitochondrial Subpopulation Dynamics in Stem Cells

Figure 1

Mitochondrial heterogeneity between tissue types and within cells. (a)–(e) Transmission electron micrographs depicting mitochondrial features in mouse liver ((a), enlarged in (b)), mouse heart ((c), enlarged in (d)), and a primary-stage human oocyte (e). (f) A fluorescent micrograph depicting JC-1-labeled KGN cells demonstrates heterogeneity in mitochondrial membrane potential between cells and between individual subcellular mitochondrial populations. JC-1 monomers (green) indicate low Δψm and JC-1 aggregates (red) indicate high Δψm. Scale bars as marked.

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