Review Article
Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley?
Table 2
Preclinical models of S-AKI and the effect of MSC.
| | Team/year | Animal model | Type of MSC/combination | Effect of MSC | Ref. |
| | Luo et al. (2014) | CLP-polymicrobial mouse model | Unspecified MSC (1 × 106) | ↓ urea, creatinine
↓ IL-17, CXC, CCL
↓ ATN score | [41] | | Cóndor et al. (2016) | CLP-polymicrobial rat | WJ-MSC (1 × 106) | ↑ glomerular filtration (inulin clearance)
↓ apoptosis intensity in the renal parenchyma
↓ kidney infiltration by immunocompetent cells | [42] | | Sung et al. (2013) | CLP-polymicrobial mouse model | Apoptotic MSC
(1.2 × 106) | ↓ TNF-α
↓ serum creatinine | [43] | | Tsoyi et al. (2016) | CLP-polymicrobial mouse (BALB/C) | MSC (2.5–5 × 105)
CO preconditioning | ↓ incidence of AKI | [44] | | Sung et al. (2016) | CLP-polymicrobial mouse model l | A-MSC (5 × 105)/ciprofloxacin (3 mg/kg/5 days) | ↓ expression of proinflammatory cytokines in the kidney | [45] | | Chen et al. (2014) | CLP-polymicrobial rat | A-MSC (1.2 × 106)/melatonin (20 mg/kg) | ↓ levels of proinflammatory cytokines
↓ expression of NF-κB in the kidney | [46] |
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WJ-MSC = MSC derived from Wharton’s jelly; AKI = acute kidney injury; CO = carbon monoxide.
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