Induced Pluripotent Stem Cells Reduce Progression of Experimental Chronic Kidney Disease but Develop Wilms’ Tumors

Figure 3

The macroscopic and microscopic image shows tumors formed by induced pluripotent stem cells (iPSs) infused into the renal parenchyma after 60 days. (a) Kidney from wild-type rat shows normal size and appearing, while (b) and (c) represent macroscopic image of the cut surface of the kidney tumor. (d) Photomicrography of a chronic injured kidney showing loss of the renal architecture as a result of a high cellularity in the renal interstitium. Masson-trichrome staining. Bar: 500 μm; (e) perirenal tissues infiltrated with tumoral cells () Masson-trichrome staining. Bar: 500 μm. (f, g) Photomicrography of the tumoral area showing tumor cells surrounded by extracellular matrix (ECM) () and organized in rows or nests resembling blastemal tissue (). Masson-trichrome staining. Bar: 200 μm.

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