NURR1 Downregulation Favors Osteoblastic Differentiation of MSCs

Table 1

Osteogenic markers in DPSC cultures: NURR1 silenced versus CTRs.

	2 days	4 days	6 days	8 days
ALP	UN	+	++	++
Col1	UN	++	++	++
Runx-2	+	UN	+	−
OPG	UN	−	−	++
OPN	+	−	−	UN
OCN	NF	NF	+	+

The table reports the osteogenic markers analyzed at 2, 4, 6, and 8 days of differentiation in NURR1 silenced and CTR cultures. The symbols indicate the ratio of NURR1 SIL compared to CTR cultures (expressed as %). + corresponds to an increase 10–50%; ++ corresponds to an increase higher than 50%; − corresponds to a decrease 10–50%; UN indicates a not significant variation; NF indicates a not relevant detection of the marker.