Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells

Figure 4

Schema of osteogenic differentiation through the BMP-2 signaling pathway. Type I and type II BMP receptors span the cell membrane and bind extracellular BMP ligand. Ligand binding to BMP receptor complexes activates signaling through type II-receptor-mediated phosphorylation of the type I receptor. In bottom-up release system, the probability of BMP-2 binding to receptors was maximized during BMP-2 treatment process.