Research Article
Therapeutic Potential of Multilineage-Differentiating Stress-Enduring Cells for Osteochondral Repair in a Rat Model
| (a) Filling of the defect relative to surface of normal adjacent cartilage |
| | 4 W | 12 W | | Control | Non-Muse | Muse | Control | Non-Muse | Muse |
| | 2.0 ± 0.7 | 2.0 ± 0 | 1.2 ± 0.4 | 2.0 ± 0.8 | 2.2 ± 0.4 | 1.0 ± 1.1 |
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| (b) Integration of repair tissue with surrounding articular cartilage |
| | 4 W | 12 W | | Control | Non-Muse | Muse | Control | Non-Muse | Muse |
| | 3.0 ± 0 | 3.0 ± 0 | 3.0 ± 0 | 3.0 ± 0 | 3.0 ± 0 | 0 ± 0 |
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| (c) Matrix staining with safranin O/fast green |
| | 4 W | 12 W |
| | Control | Non-Muse | Muse | Control | Non-Muse | Muse | | 4.0 ± 0 | 4.0 ± 0 | 4.0 ± 0 | 4.0 ± 0 | 4.0 ± 0 | 4.0 ± 0 |
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| (d) Cellular morphology (choose first between a, b, c, and d) |
| | 4 W | 12 W | | Control | Non-Muse | Muse | Control | Non-Muse | Muse |
| | 5.0 ± 0 | 5.0 ± 0 | 5.0 ± 0 | 5.0 ± 0 | 5.0 ± 0 | 5.0 ± 0 |
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| (e) Architecture within the entire defect (not including margins) |
| | 4 W | 12 W | | Control | Non-Muse | Muse | Control | Non-Muse | Muse |
| | 2.8 ± 1.3 | 3.5 ± 1.2 | 0.2 ± 0.4 | 3.0 ± 1.1 | 1.0 ± 0 | 0 ± 0 |
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| (f) Architecture of surface |
| | 4 W | 12 W | | Control | Non-Muse | Muse | Control | Non-Muse | Muse |
| | 1.6 ± 0.9 | 2.0 ± 0.6 | 1.2 ± 0.4 | 2.8 ± 0.5 | 3.0 ± 0 | 1.0 ± 0 |
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| (g) Percentage of new subchondral bone |
| | 4 W | 12 W | | Control | Non-Muse | Muse | Control | Non-Muse | Muse |
| | 3.8 ± 0.4 | 4.0 ± 0 | 1.0 ± 0.7 | 4.0 ± 0 | 3.0 ± 0 | 0.3 ± 0.5 |
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| (h) Formation of tidemark |
| | 4 W | 12 W | | Control | Non-Muse | Muse | Control | Non-Muse | Muse |
| | 4.0 ± 0 | 4.0 ± 0 | 1.8 ± 1.1 | 4.0 ± 0 | 3.8 ± 0.4 | 0.5 ± 0.5 |
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Significantly better than control ().
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