Rationale and Design of the First Double-Blind, Placebo-Controlled Trial with Allogeneic Adipose Tissue-Derived Stromal Cell Therapy in Patients with Ischemic Heart Failure: A Phase II Danish Multicentre Study

Table 3

Mesenchymal stromal cell trials in patients with acute myocardial infarction.

Reference	Number of patients	Cell type	Design	Delivery route	Endpoints
Allogeneic
Hare et al. 2009 [17]	53	MSC	RPCT	IV	Safe. Improved FEV1
Autologous
Chen et al. 2004 [18]	69	MSC	RPCT	IC	Improved LVEF, LVESV, perfusion
Katritsis et al. 2007 [19]	22	MSC	Open	IC	Improved wall motion and perfusion
Yang et al. 2010 [20]	16	MSC	Open	IC	Safe and feasible. No clinical improvement
Houtgraaf et al. 2012 [21]	14	MSC	RPCT	IC	Improved perfusion and reduced scar tissue

FEV1: forced expiratory volume in 1 second; IC: intracoronary; IV: intravenous; LV: left ventricular; LVEF: left ventricular ejection fraction; RPCT: randomised placebo controlled trial.