The Impact of CRISPR/Cas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Advantages</td><td class="align_center">Disadvantages</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Target design simplicity</td><td class="align_center">Limited number of PAM sequences</td></tr><tr><td class="align_left">Multiplexed target recognition</td><td class="align_center">Off-site effects</td></tr><tr><td class="align_left">Efficiency for editing different human cells</td><td class="align_center">Mosaicism</td></tr><tr><td class="align_left">Screening DNA noncoding regions</td><td class="align_center">Multiple alleles</td></tr><tr><td class="align_left"> </td><td class="align_center">Ethical issues</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Summary of CRISPR advantages and disadvantages.

Stem Cells International

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Table 1

Table 1: The Impact of CRISPR/Cas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches 