Transplanted Adult Neural Stem Cells Express Sonic Hedgehog In Vivo and Suppress White Matter Neuroinflammation after Experimental Traumatic Brain Injury

<div>Adult NSC in vitro characterization and NSC-host response after transplantation. (a) In vitro growth curve of cumulative cells generated demonstrates proliferation. (b) In vitro confirmation of multipotency by quantification of differentiated cells immunolabeled for distinct lineage markers: astrocytes with GFAP, neurons with MAP-2, or oligodendrocytes with O4. (c) NSCs ubiquitously expressing green fluorescent protein (NSC-GFP) formed processes 1 week following transplantation into the parenchyma adjacent to the lateral ventricle (LV). Sections were counterstained with 4′,6-diamidino-2-phenylindole (DAPI, blue). Scale bar = 50 <i>μ</i>m (c).</div>

Stem Cells International

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Figure 1: Transplanted Adult Neural Stem Cells Express Sonic Hedgehog In Vivo and Suppress White Matter Neuroinflammation after Experimental Traumatic Brain Injury 

Figure 1 | Transplanted Adult Neural Stem Cells Express Sonic Hedgehog In Vivo and Suppress White Matter Neuroinflammation after Experimental Traumatic Brain Injury 