|
| Topography | Materials | Dimensions | Cells | Outcome |
|
| Film | Chitosan [90] | | NSCs from cortex of E12 fetal rats | Proliferation ↑; astrocytes ↑ |
| Film | Ultrananocrystalline diamond (UNCD) [91] | | NSCs from cortex of E11.5 rat embryos | Proliferation most on
hydrogen-terminated
UNCD film; neuronal
differentiation most on
oxygen-terminated UNCD film |
| Film | PHA: PLA, PHBVHHx [92] | | NSCs from neocortex of E13–15 rat embryos | Adsorption and proliferation
more on PHBVHHx film;
neuronal differentiation and
neurite outgrowth more on PLA film |
| Hydrogel | Gelatin-hydroxyphenylpropionic acid (Gtn-HPA) [93] | | NSCs from hippocampus of adult female Fischer 344 rats | Viability ↑; proliferation rate ↓;
the expression of GFAP ↑;
the expression of Tuj-1 ↑ |
| Hydrogel | Hyaluronic acid (HA) [94] | | NSCs from induced pluripotent stem cells | Glial, neuronal, or immature/progenitor states ↑; proliferation ↑ |
| Hydrogel | Polyethylene glycol [99] | | NSCs from the BMSCs of 4 weeks SD rats | Viability ↑; proliferation ↑ slightly;
neuron ↑; neurite outgrowth and extension |
| Nanofibers | Polyethersulfone (PES) [100] | 283 nm, 749 nm, 1452 nm | NSCs from hippocampus of adult rats | 40% ↑ in oligodendrocyte with
283 nm fibers; 20% ↑ in neuronal cells with 749 nm fibers; proliferation ↑; cell spreading ↑; cell aggregation ↓ with the decrease of fiber diameter |
| Nanofibers | Polyhydroxyalkanoates (PHA): PHB, P3HB4HB, PHBHHx [101] | | NSCs from neocortex of E13–15 rat embryos | Proliferation and neuronal differentiation most in PHBHHx |
| Nanofibers | Poly-ε-caprolactone (PCL) [102] | 550 ± 100 nm | NSCs from neocortex of E14.5 rat embryos | Proliferation ↑; neurons ↑; oligodendrocytes ↑ |
|
