Research Article
NADPH Oxidase Signaling Pathway Mediates Mesenchymal Stem Cell-Induced Inhibition of Hepatic Stellate Cell Activation
Figure 5
The pathways of NADPH oxidase are involved in hBM-MSC-induced reduction in liver fibrosis. The cocultures and activated HSCs were pretreated with or without 1 μM DPI for 1 hour, and then cells were harvested after cultured for 72 hours. (a–c) The mRNA levels of PPARγ, α-SMA, and α1(I) collagen were, respectively, detected by real-time PCR (). versus the control group. versus the control group. versus activated HSCs plus DPI. (d) The proteins of PPARγ, α-SMA, and α1(I) collagen were evaluated by Western blot. versus the control group. versus the control group.
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