|
| Species | DNA m6dA distribution | Functions |
|
| D. melanogaster | Transposons, intergenic regions, nucleosomal biased, preferential for repeat sequences | Promotion of transposon expression |
| Repression of many genes involved in CNS functions |
| Promote GSC differentiation |
|
| C. reinhardtii | TSS of more than 14,000 genes actively | Mainly promote gene transcription |
| Linker DNA biased |
| Intergenic regions |
|
| C. elegans | No preference in the genome | Mainly promote gene transcription |
| Nucleosomal biased |
|
| T. thermophilus | 5 end of the gene body | Enhance transcription of the genes bearing m6dA sites |
| AT motif of the linker DNA regions flanked by nucleosomes particularly |
| H2A.Z-containing nucleosomes associated with Pol II-transcribed genes |
|
| Danio rerio | Preferential for repeat sequences | |
|
| Xenio laevis | Depleted at TSSs | |
|
| Mus musculus | Depleted at TSSs, enriched on LINE-1 in ESC | Epigenetic silencing of LINE-1 and surrounding |
| Varies in accordance with physiological conditions | Enhancers and genes |
| Involved in ESC self-renewal and differentiation |
|
| Homo sapiens | Depleted at TSSs, enriched on LINE-1 | Similar to mouse |
|
| Species | RNA m6A | Biological functions |
| Mammals | 5UTR and 3UTR | Regulation of gene expression |
| Stop codon | RNA metabolism including mRNA, rRNA, tRNA, miRNA, snoRNA, and circRNA |
| Low abundance in coding regions long introns |
| | Determination of cell fate |
|
