The Myc/Max/Mxd Network Is a Target of Mutated Flt3 Signaling in Hematopoietic Stem Cells in Flt3-ITD-Induced Myeloproliferative Disease

Figure 3

Flt3-ITD mice have altered frequencies of hematopoietic stem and progenitor cells. Next, we subdivided the hematopoietic stem cell compartment into long-term HSCs (LT-HSCs) and MPPs, utilizing the SLAM receptor staining with CD150 and CD48, and cells were sorted by flow cytometry for subsequent gene expression analysis.