Conditioned Medium from Human Amnion-Derived Mesenchymal Stem Cells Regulates Activation of Primary Hepatic Stellate Cells

<div>Effect of hAMSC-CM on TGF-β1-induced HSC activation. Gene expression analysis of HSCs with or without TGF-β1 in SM or hAMSC-CM, analyzed by qRT-PCR for (a) <i>Tgfbr1</i>, (b) <i>α-Sma</i>, and (c) ECM-related genes. (d) Relative <i>Mmp-13/Timp-1</i> expression ratio. 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550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path></g></svg> versus SM; <svg height="12.4111pt" id="M26" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.7741 54.5994 12.4111" width="54.5994pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M278 -108C276 -72 276 -41 276 6C276 132 289 239 307 279C282 327 275 360 273 404C334 402 369 393 402 372C420 379 445 401 457 422C445 442 420 464 402 471C369 449 334 441 273 439C276 506 281 532 311 583C297 609 275 635 252 647C231 635 207 609 194 583C223 532 229 506 232 439C171 442 135 450 103 471C84 463 60 441 49 422C60 401 84 379 103 372C135 393 171 402 232 404C230 360 224 327 199 279C217 239 228 132 228 6C229 -41 229 -72 227 -108H278Z" id="g50-15"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.615,-5.741)"><path d="M278 -108C276 -72 276 -41 276 6C276 132 289 239 307 279C282 327 275 360 273 404C334 402 369 393 402 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Stem Cells International

fig4

Figure 4

Figure 4: Conditioned Medium from Human Amnion-Derived Mesenchymal Stem Cells Regulates Activation of Primary Hepatic Stellate Cells 