Alteration in the Cytokine Secretion of Bone Marrow Stromal Cells from Patients with Chronic Myelomonocytic Leukemia Contribute to Impaired Hematopoietic Supportive Activity

<div>Analysis of hematopoietic colony-forming units on methylcellulose after coculture of CB CD34<sup>+</sup> cells with HD-BMSCs or CMML-BMSCs. (a) After a 3-day coculture of CB CD34<sup>+</sup> cells with HD-BMSCs or CMML-BMSCs, the CFU-C assays were performed with 500 cells collected from the upper chamber. After 14 days of culture in H4435 methylcellulose, colonies of CFU-GEMM, CFU-GM, and BFU-E derived from coculture with HD-BMSCs or CMML-BMSCs were enumerated. 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602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,40.505,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path></g><g transform="matrix(.013,0,0,-0.013,43.469,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,49.709,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path></g></svg>.</span> (b) Representative flow dot plots show the percentage of myeloid (CD45<sup>+</sup>CD33<sup>+</sup>) or erythroid (CD71<sup>+</sup>CD235a<sup>+</sup>) cells after a 3-day coculture of CB CD34<sup>+</sup> cells with HD-BMSCs or CMML-BMSCs followed by 14 days of culture on methylcellulose. Quantification of the percent myeloid and erythroid populations is shown. 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Stem Cells International

fig3

Figure 3

Figure 3: Alteration in the Cytokine Secretion of Bone Marrow Stromal Cells from Patients with Chronic Myelomonocytic Leukemia Contribute to Impaired Hematopoietic Supportive Activity 

Figure 3 | Alteration in the Cytokine Secretion of Bone Marrow Stromal Cells from Patients with Chronic Myelomonocytic Leukemia Contribute to Impaired Hematopoietic Supportive Activity 