Alteration in the Cytokine Secretion of Bone Marrow Stromal Cells from Patients with Chronic Myelomonocytic Leukemia Contribute to Impaired Hematopoietic Supportive Activity

Figure 4

Comparison of cytokine secretion in CMML-BMSCs and HD-BMSCs. Cytokine array was performed to analyze the expression levels of soluble cytokines between HD-BMSCs and CMML-BMSCs. (a) Representative photographs showed that IL-6 (surrounded by blue lines), IL-8 (surrounded by red line), and GRO-β (surrounded by green line) significantly decreased in CMML-BMSCs compared with HD-BMSCs. (b) Quantitative analysis of the cytokine array using IQTL 7.0 software. Data are presented as the (), . (c) ELISA assay was performed to validate the altered cytokine secretion in cytokine array (HD-BMSCs, ; CMML-BMSCs, ). Data are presented as the , and .

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