Mesenchymal Stem Cells in Oriented PLGA/ACECM Composite Scaffolds Enhance Structure-Specific Regeneration of Hyaline Cartilage in a Rabbit Model

Table 3

International Cartilage Repair Society Visual Histological Assessment Scale for Cartilage Repair.

Feature	Points
I. Surface
Smooth/continuous	3
Discontinuities/irregularities	0
II. Matrix
Hyaline	3
Mixture: hyaline/fibrocartilage	2
Fibrocartilage	1
Fibrous tissue	0
III. Cell distribution
Columnar	3
Mixed/columnar clusters	2
Clusters	1
Individual cells/disorganized	0
IV. Cell population viability
Predominantly viable	3
Partially viable	1
<10% viable	0
V. Subchondral bone
Normal	3
Increased remodeling	2
Bone necrosis/granulation tissue	1
Detached/fracture/callus at base	0
VI. Cartilage mineralization (calcified cartilage)
Normal	3
Abnormal/inappropriate location	0