Altered Expression of Hematopoiesis Regulatory Molecules in Lipopolysaccharide-Induced Bone Marrow Mesenchymal Stem Cells of Patients with Aplastic Anemia

Figure 2

Expression of the hematopoietic regulatory molecules: MIP-1α, TNF-α, G-CSF, SDF-1α, SCF, and TGF-β1. (a) Relative fold changes in mRNA expression of hematopoietic regulatory cytokine genes in AA BM-MSCs as compared to control BM-MSCs by qRT-PCR after LPS stimulation. (b) Levels of the hematopoietic regulatory molecules in culture supernatants of LPS-stimulated AA and control BM-MSCs as detected by ELISA. (c) Levels of the hematopoietic regulatory molecules in the BM plasma of AA patients and controls as detected by ELISA. Values represent mean ± SE. , , and between AA patients and controls.

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