Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction

Table 1

Clinical trials of MSC transplantation for treating MI.

Clinical trials	Phase	Dose (10^6)	Delivery route	Enrollment	Infarct scar	LVEF	Following up	Study	Reference
NCT00114452	Phase 1	0.5/1.6/5	IC	53	n.a.	↑	6 m	Hare et al. (2009)	[25]
NCT00677222	Phase 1	100	IC	30	n.a.	↑	4 m	Penn et al. (2012)	[26]
2011AA020109	Phase 1	3.08	IC	43	=	↑	12 m	Gao et al. (2013)	[27]
UO1 HL087318–04	Phase 1	150	IC	65	↓	↑	12 m	Traverse et al. (2014)	[28]
NCT01234181	Phase 1	100	IC	22	↓	↑	12 m	Hu et al. (2015)	[29]
NCT01087996	Phase 1/2	20	IM	30	↓	↑	13 m	Hare et al. (2012)	[30]
U54HL081028	Phase 1/2	20	IM	30	↓	↑	13 m	Suncion et al. (2014)	[31]
NCT02323477	Phase 1/2	20	IM	79	n.a.	n.a.	12 m	Can et al. (2015)	[32]
NCT00883727	Phase 1/2	180–220	IV	20	=	=	2 y	Chullikana et al. (2015)	[33]
NCT02504437	Phase 1/2	—	—	200	—	—	12 m	Pei (2015–2017)	ClinicalTrials.gov
NCT02503280	Phase 1/2	200	—	55	—	—	12 m	Joshua (2015–2032)	ClinicalTrials.gov
NCT02666391	Phase 1/2	—	—	64	—	—	18 m	Pei (2016–2017)	ClinicalTrials.gov
NCT01770613	Phase 2	—	—	—	—	—	12 m	Nabil (2013–2017)	ClinicalTrials.gov
NCT00684021	Phase 2	150	IC	101	n.a.	↑	6 m	Schutt et al. (2015)	[34]
NCT00984178	Phase 2	15	IC	120	↓	↑	12 m	San Roman et al. (2015)	[35]
NCT00765453	Phase 2	59.8	IC	100	n.a.	↑	12 m	Choudry et al. (2015)	[36]
NCT01291329	Phase 2	6	IC	116	↓	↑	18 m	Gao et al. (2015)	[37]
NCT03047772	Phase 2	—	—	124	—	—	12 m	Yang (2017–2018)	ClinicalTrials.gov
NCT00877903	Phase 2	—	IV	220	—	—	5 y	Donna (2009–2018)	ClinicalTrials.gov
NCT02013674	Phase 2	100	IM	30	↓	↑	12 m	Florea et al. (2013–2019)	[38]
NCT01392105	Phase 2/3	72	IC	80	n.a.	↑	6 m	Lee et al. (2014)	[39]
NCT03404063	Phase 2/3	30		115	—	—	6 m	Piotr (2017–2020)	ClinicalTrials.gov
NCT01394432	Phase 3	—	IM	50	—	—	12 m	Evgeny (2012–2016)	ClinicalTrials.gov
NCT01652209	Phase 3	—	—	135	—	—	13 m	Yang (2013–2020)	ClinicalTrials.gov
NCT02672267	Phase 3	—	IM	50	—	—	6 m	Saule (2014–2016)	ClinicalTrials.gov

MSCs: mesenchymal stem cells; MI: myocardial infarction; IM: intramyocardial; IC: intracoronary; IV: intravenous; LVEF: left ventricular ejection fraction; y: year; m: month; n.a.: not analyzed; =: no statistical significance. , , and .