D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion

<div>D-mannose inhibited IL-6 secretion of hPDLSCs to induce more T cell differentiation into Tregs. (a) Compared with T + G-hPDLSCs, less IL-6 could be detected in T + M-hPDLSCs. (b, c) Anti-IL-6 could increase the FoxP3 level in T + G-hPDLSCs. (d, e) Increased IL-6 could reduce the FoxP3 level in T + M-hPDLSCs. Student’s <i>t</i>-test was used to analyze statistical significance. All error bars represent s.d. 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Stem Cells International

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Figure 3

Figure 3: D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion 