Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

Figure 2

HAT regulate cancer stem cells through different mechanisms. HAT promote a cancer stem cell phenotype by inducing chromatin modifications (a), acting as a transcriptional coactivator (b) or acetylating cancer stem cell transcription factors (c). HAT can also constitute chimeric proteins as a result of chromosome translocation (d), which possess aberrant HAT activities.

(a)

(b)

(c)

(d)