IGF-1-Overexpressing Mesenchymal Stem/Stromal Cells Promote Immunomodulatory and Proregenerative Effects in Chronic Experimental Chagas Disease

Figure 4

Cytokine evaluation in the heart and serum after cell therapy. Samples or infected mice treated with saline, MSCs, or MSC_IGF-1 were collected two months following the initiation of the cell therapy protocol and analyzed by RT-qPCR in the heart tissue for gene expression (a–d) and by ELISA in the serum for protein quantification (e–h) of TNF-α (a, e), IFN-γ (b, f), IL-10 (c, g), and TGF-β (d, h). Data represent the of 5–7 mice per group. , , , and compared to other groups.

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