IGF-1-Overexpressing Mesenchymal Stem/Stromal Cells Promote Immunomodulatory and Proregenerative Effects in Chronic Experimental Chagas Disease

Figure 5

Proregenerative effects of therapy with MSC_IGF-1 in the skeletal muscle. Representative images of skeletal muscle sections stained with H&E, obtained from naïve (a) or infected mice treated with saline (b), MSCs (c), or MSC_IGF-1 (d), showing destruction of myofibers and substitution for fibrosis and adipose tissue in infected mice, when compared to naïve mice, and recovery in MSC_IGF-1-treated mice (d). Skeletal myosin staining in skeletal muscle sections from naïve (e) or infected mice (f) treated with saline (g), MSCs (h), or IGF-1 (i), confirming the enhanced presence of myosin⁺ myofibers in MSC_IGF-1-treated mice. . (j) Quantification of the skeletal myosin⁺ area. and .

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