The Milk Thistle (Silybum marianum) Compound Silibinin Inhibits Cardiomyogenesis of Embryonic Stem Cells by Interfering with Angiotensin II Signaling

Figure 1

Effect of increasing doses of silibinin on (a) the number of contracting cardiac foci differentiated from ES cells (), (b) the size of cardiac foci (), and (c) the contraction frequency (). (d) Image shows the decay in contraction frequency over time following treatment with 20 μM silibinin (). The images in (b) show representative cardiac cell areas immunolabeled with an antibody against α-actinin. The bar represents 300 μm. , significantly different to the untreated control.

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