FoxO1 Overexpression Ameliorates TNF-<i>α</i>-Induced Oxidative Damage and Promotes Osteogenesis of Human Periodontal Ligament Stem Cells via Antioxidant Defense Activation

<div>FoxO1 overexpression reduced TNF-<i>α</i>-induced apoptosis in hPDLSCs. Apoptosis was detected in PDLSC-pMSCV-empty (NC) and PDLSC-pMSCV-FoxO1 (ov-FoxO1) by Annexin V/7-AAD flow cytometry following treatment with <i>α</i>-MEM or TNF-<i>α</i> (10 ng/mL) for 72 h (a). Quantification of apoptotic cells presented as the percentage of the total cells (b). 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Stem Cells International

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Figure 3

Figure 3: FoxO1 Overexpression Ameliorates TNF-<i>α</i>-Induced Oxidative Damage and Promotes Osteogenesis of Human Periodontal Ligament Stem Cells via Antioxidant Defense Activation 

Figure 3 | FoxO1 Overexpression Ameliorates TNF-α-Induced Oxidative Damage and Promotes Osteogenesis of Human Periodontal Ligament Stem Cells via Antioxidant Defense Activation 