Potential Role of the Resident Mesenchymal Stem-Like Cells in Renal Fibrogenesis after Ureteral Obstruction

Figure 6

The number and pattern of fibrosis genes that up- and downregulated over 2-fold in the ex vivo expanded cells from renal tissues. (a) Total numbers of genes that up- and downregulated over 2-fold in the twice-passaged MSLCs of the unobstructed and obstructed groups when comparing to the sham group. According to the biological functions, these genes with over 2-fold change are also categorized into ECM structural constituents and remodeling enzymes (b), inflammatory cytokines and chemokines (c), transcription factors and other factors (d), TGF-beta superfamily members (e), cell adhesion molecules (f), and growth factors (g).

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