In Vivo MRI Tracking of Mesenchymal Stromal Cells Labeled with Ultrasmall Paramagnetic Iron Oxide Particles after Intramyocardial Transplantation in Patients with Chronic Ischemic Heart Disease

Figure 6

NOGA injection points and T2 relaxation time difference maps. Images are from the same patient as Figure 4. The left image shows the NOGA™ injection map of the patient’s left ventricle after injections. The colors represent endocardial voltage in mV with the lowest voltages of nonviable tissue (red). Injection points of USPIO-labeled MSCs are shown as yellow points on the map, and brown points represent injection points of unlabeled MSCs. The images on the right shows regional differences in T2 relaxation (ms) time from baseline to day 0 (D0), baseline to day 1 (D1), baseline to day 3 (D3), and baseline to day 7 (D7). A = anterior; L = lateral; I = inferior; S = septum; USPIO = ultrasmall paramagnetic iron oxide; MSC = mesenchymal stromal cell.