miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart

Figure 5

CPC^ISX-9-derived EV reversed cardiac remodeling in infarcted mice. (a) Representative M-mode echocardiography images from three groups 30 days after MI. LVDs (b), LVDd (c), EF (d), and FS (e) are shown. vs. the PBS group, ; # vs. the EV-iPSC group, . PBS group: , EV-iPSC group: , and EV-CPC^ISX-9 group: . EF: ejection fraction; FS: fractional shortening; LVDd: diastolic left ventricular dimensions; LVDs: systolic left ventricular dimensions. (f) Representative Masson’s trichrome-stained sections of hearts from the three groups. (g) Quantitative estimate of fibrosis. vs. the PBS group, ; # vs. the EV-iPSC group, , .

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