Effects of Placenta-Derived Mesenchymal Stem Cells on the Particulate Matter-Induced Damages in Human Middle Ear Epithelial Cells

Figure 3

Changes in mRNA expression levels of human middle ear epithelial cells (HMEECs) after particulate matter (PM) treatment and coculture with placenta-derived mesenchymal stem cells (PL-MSCs). The mRNA levels of IL1β, TNFα, IL6, COX2, and MUC5B were increased after PM treatment. The increased expression of IL1β, TNFα, IL6, and MUC5B was alleviated after coculture with PL-MSCs. The expression of COX2 was higher under coculture conditions than monoculture conditions (interleukin 1 beta (IL1β), tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), cyclooxygenase 2 (COX2), and mucin 5B (MUC5B)).