The Effect of Vascular Endothelial Growth Factor on Bone Marrow Mesenchymal Stem Cell Engraftment in Rat Fibrotic Liver upon Transplantation

Table 2

Laennec scoring system for staging fibrosis in liver biopsies.

Stage	Name	Septa (thickness and number)	Criteria	Score
0	No definite fibrosis			0
1	Minimal fibrosis	+/−	No septa or rare thin septum; may have portal expansion or mild sinusoidal fibrosis	1
2	Mild fibrosis	+	Occasional thin septa; may have portal expansion or mild sinusoidal fibrosis	2
3	Moderate fibrosis	++	Moderate thin septa; up to incomplete cirrhosis	3
4A	Cirrhosis, mild, definite, or probable	+++	Marked septation with rounded contours or visible nodules. Most septa are thin (one broad septum allowed)	4
4B	Moderate cirrhosis	++++	At least two broad septa, but no very broad septa and less than half of biopsy length composed of minute nodules	5
4C	Severe cirrhosis	+++++	At least very broad septum or more than half of biopsy length composed of minute nodules	6