Alveolar Differentiation Potency of Human Distal Airway Stem Cells Is Associated with Pulmonary Pathological Conditions

Figure 4

DASC phenotype from normal and diseased lungs. (a) Representative cell culture images of DASCs generated from bronchiectasis, COPD, ILD, and normal lungs. Scale bar, 50 μm. (b) Representative images of monolayer-differentiated DASCs from bronchiectasis, COPD, ILD, and normal lungs. Scale bar, 50 μm. (c) Immunostaining of HOPX expression on monolayer-differentiated DASCs from bronchiectasis, COPD, ILD, and normal lungs. Scale bar, 50 μm. (d) Quantification of alveolar differentiation potency of DASCs generated from bronchiectasis, COPD, ILD, and normal lungs. Horizontal lines represent the mean within groups, with standard deviation error bars. Normal refers to healthy volunteers with normal spirometry.

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