Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line

Figure 1

OSKM-N proteins are expressed in cervical cancer. (a) Expression levels of OCT4 (i), SOX2 (ii), KLF4 (iii), C-MYC (iv), and NANOG (v) proteins in cervical cancer tumors were measured by western blot (WB). Tumor samples (T1-T10) were compared with a nontumor sample (NT1). WB experiments were performed in triplicate; the values are expressed as (normalized to β-actin) using densitometric analysis. (b) The expression of OSKM-N in tumor cells from T1 and T2 samples was observed by immunohistochemistry (arrows). ×20 magnification. , , , .

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