Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line

<div>HaCaT cell line increases the efficiency of sphere formation in the presence of the OSKM-N factors. OSKM-N gene overexpression enhances cancer stem cell properties in HaCaT cells. HaCaT cells were cotransfected with OSKM-N gene plasmids and cultured in sphere-forming media. (a) Spheres formed by HaCaT cells compared with HaCaT transfected with OCT4, SOX2, KLF4, C-MYC, NANOG, and a combination of SOX2 plus NANOG (SN). (b) Efficiency of sphere formation of OSKM-N gene-transfected HaCaT cells and (c) length of sphere. The scale bar is 50 <i>μ</i>m. 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Stem Cells International

fig4

Figure 4

Figure 4: Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line 

Figure 4 | Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line 