Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line

Figure 5

OSKM-N factors segregate tumor cells and nontumor cells from different tissues. The meta-analysis of cDNA microarrays reported for cervical cancer showed a difference in expression profiles between cervical cancer biopsies and normal cervical tissue. (a) The analysis evaluates, through a heat map, each factor separately, (b) using the OSKM-N factors together and (c) OSKM-N factors together with other associated genes regulated by these factors. The color red or green in cells reflects low or high relative expression levels, respectively.

(a)

(b)

(c)