Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma

Figure 2

Therapeutic potential of DP-MSCs in glaucoma treatment. Dental pulp represents valuable and easily accessible sources for DP-MSCs which are able to differentiate into functional retinal ganglion cells (RGCs) under appropriate culture conditions (a). Intravitreally transplanted DP-MSCs produce several neurotrophic factors (platelet-derived growth factor (PDGF), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF)) which promote survival of RGCs and induce regeneration of injured axons (b).

(a)

(b)