Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes

<div>Immunomodulatory effects on activated T cells cocultured with AdMSCs, iM<i>Φ</i>, and AdMSCs+iM<i>Φ</i>. (a) Proliferation of PBMCs cocultured with various cells for 72 h was analyzed by a WST-based proliferation assay kit to examine suppression of PBMCs by the different cells. (b) Relative gene expression of FoxP3 was significantly increased in iM<i>Φ</i>-alone culture condition. (c) The relative gene expression levels of <i>IL-10</i> and <i>TSG-6</i>, immunomodulatory- and anti-inflammatory-related factors, were evaluated by qPCR. 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Stem Cells International

fig2

Figure 2

Figure 2: Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes 