Research Article

Islet1 and Brn3 Expression Pattern Study in Human Retina and hiPSC-Derived Retinal Organoid

Figure 3

Double immunolabeling of Islet1 and HuD in human fetal retinal and retinal organoid. (a–f) HuD coexpressed with Islet1 in GCL during the early stage of fetal retina development. From Fwk 16, a subpopulation of HuD-positive and Islet1-negative amacrine cells appeared in the INL. (g–l) HuD showed a similar expression pattern in retinal organoids. From Dwk 24, double-positive cells disappeared, and only HuD-single-positive amacrine cells organized as rosettes in the retinal organoid ().