Research Article

Islet1 and Brn3 Expression Pattern Study in Human Retina and hiPSC-Derived Retinal Organoid

Figure 6

Islet1 expression and postmitotic amacrine marker, AP2α. (a–f) Amacrine cell developed as early as Fwk 9 and then organized in the inner side of the INL, without coexpression of Islet1. (g–l) In the retinal organoid, AP2α-positive amacrine cell was observed at Dwk 13, later than in the fetal retina. Until Dwk 16, the number of amacrine cells obviously increased but was organized as rosettes. Until Dwk 31, the AP2α-positive cells showed a disorderly arrangement ().