Effects of Stromal Cell-Derived Factor-1<i>α</i> Secreted in Degenerative Intervertebral Disc on Activation and Recruitment of Nucleus Pulposus-Derived Stem Cells

<div>The expression of SDF-1<i>α</i> in the degenerative IVD condition. The levels of synthetic mRNA (a) and secreted protein (b) of SDF-1<i>α</i> from NPCs after treatment with the proinflammatory cytokines IL-1<i>β</i> and TNF-<i>α in vitro</i>. (c) Histological analysis of the relationship between IVD degeneration and SDF-1<i>α</i> expression. SDF-1<i>α</i>: stromal cell-derived factor-1<i>α</i>; IVD: intervertebral disc; NPCs: nucleus pulposus cells; IL-1<i>β</i>: interleukin-1<i>β</i>; TNF-<i>α</i>: tumor necrosis factor-<i>α</i>; H&amp;E: hematoxylin and eosin; IHC: immunohistochemistry. 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Stem Cells International

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Figure 4

Figure 4: Effects of Stromal Cell-Derived Factor-1<i>α</i> Secreted in Degenerative Intervertebral Disc on Activation and Recruitment of Nucleus Pulposus-Derived Stem Cells 

Figure 4 | Effects of Stromal Cell-Derived Factor-1α Secreted in Degenerative Intervertebral Disc on Activation and Recruitment of Nucleus Pulposus-Derived Stem Cells 