Expression of Potential Dermal Progenitor Cell Markers in the Tumour and Stroma of Skin Adnexal Malignant and Benign Tumours

Figure 3

CRAPB1 expression profile: positive staining of cells lining up at the epidermal-dermal interface region and the papillary dermis ((a), black arrows) and the dermal papilla (b) and strong staining of sebaceous gland cells, their septates and within the surrounding papillary dermis (c). Nodular basal cell carcinoma with staining at the tumour-stroma interaction (TSI) site within the core of the tumour (as indicated by black arrows, (d)) but also within the tumour (e). Superficial basal cell carcinoma with CRABP1-positive cells at the tumour-stroma interaction site ((f), black arrows). Sclerosing basal cell carcinoma with strong expression within the inflammatory infiltrate located within the core of the tumour and its tumour-stroma interaction (TSI) site (g). Well-differentiated sebaceous carcinoma (h) with positive cells located at the tumour-stroma interaction (TSI) site within the core of the tumour and at the invasive margin (IM) of the tumour in an early porocarcinoma (i).