Review Article

Autologous Stem Cell Transplantation in Multiple Myeloma with Renal Failure: Friend or Foe?

Table 1

ASCT in myeloma patients with renal insufficiency, the characteristics of the studies.

AuthorYearCountryDiagnosis of RFRenal failure clinical stage in MM patientDialysis or not before ASCTTherapyPrognostic criteria

ASCT in myeloma patients with renal insufficiency: the cohort studies
Antlanger et al. [29]2018Austria (MDRD)ISS stage
I (14%)
II (30%)
III (54%)
NotConventional chemotherapy+ASCTeGFR (MDRD)
Gertz et al. [28]2007USAISS stage
I (0%)
II (20%)
III (80%)
NotConditioning regimen (Mel)+ASCTNR
Knudsen et al. [16]2015DenmarkISS stage
II (8%)
III (21%)
NRConditioning regimen (Mel)+ASCTNR
Mahindra et al. [27]2017USA (MDRD)Severe RFNotConditioning regimen (Mel)+ASCTNR
Raab et al. [25]2006USAISS stage
I (14%)
II (10%)
III (74%)
NRConditioning regimen (Mel)+ASCTNR
San Miguel et al. [26]2000SpanishISS stage
II (14%)
III (86%)
NotConditioning regimen (Mel)+ASCTCrCl

ASCT in myeloma patients with renal insufficiency: the retrospective analysis studies
Badros et al. [32]2001USANRNotConditioning regimen (Mel)+ASCTNR
Augeul-Meunier et al. [30]2018FranceNRDialysis dependence (47%)Conditioning regimen (Mel)+ASCTNR
Ballester et al. [34]1997USANRDialysis dependence (67%)BUCY+ASCTSCr
Balsam et al. [35]2017USAGFRCKD stage
Stage 1 (31.8%)
Stage 2 (43.8%)
Stage 3 (17.7%)
Stage 4 (3.1%)
Stage 5 (1.6%)
NotConventional chemotherapy+ASCTGFR
Bernard et al. [18]2015CanadaNRNRNotConditioning regimen (Mel)+ASCTNR
Glavey et al. [36]2011USAISS stage
I (14%)
II (10%)
III (74%)
Dialysis dependence (53%)Conditioning regimen (Mel)+ASCTCrCl
Seok Hui et al. [47]2011KoreaeGFR (MDRD)CKD stage
IIIa (78%)
IIIb (12%)
NotConditioning regimen (Mel)+ASCTeGFR (MDRD)
Parikh et al. [33]2009USANRDialysis dependence (20%)Conditioning regimen (Mel)+ASCTeGFR (MDRD)
Tosi et al. [31]2000ItalyCKD stage
IIIb (100%)
NotConventional chemotherapy+ASCTCrCl

ASCT in myeloma patients with renal insufficiency: the case report studies
Bigé et al. [39]2009FranceSCrAcute renal failureNotConditioning regimen (Mel)+ASCTSCr
Lam et al. [38]2004ChinaNormal renal functionNormal renal functionNotASCTNR
Rebibou et al. [40]1997FranceNRSevere renal failureNotConditioning regimen (Mel)+ASCTNR
Reiter et al. [37]1999AustriaNRNRNotConditioning regimen (VAD)+ASCTCrCl
Tauro et al. [41]2002UKNRNRNotConditioning regimen (Mel)+ASCTSCr

ASCT: autologous stem cell transplantation; RF: renal failure; CrCl: creatinine clearance; SCr: serum creatinine; NR: not reported; MDRD: Modification of Diet in Renal Disease; eGFR: estimated glomerular filtration rate; ISS: international staging system; CKD: chronic kidney diseases; BUCY: Busulfan and Toxicity cyclophosphamide; Mel: melphalan; GFR: glomerular filtration rate; VAD: dexamethasone.