Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells

Figure 1

ChIP-seq analyses of freshly isolated Dlk⁺ cells. (a) Distribution of H3K4me3- or H3K27me3-bound probes in the promoter regions (from -2 kb to +2 kb of the TSS). (b) Summary of H3K4me3 or H3K27me3 enrichment detected by ChIP-seq analyses. (c) Venn diagram showing the number of genes with H3K4me3 and/or H3K27me3 modifications with fold (log2). (d) Overlap of bivalent genes among the histone modification profiles in ES cells reported by Bernstein et al. [16] and hematopoietic stem cells reported by Weishaupt et al. [17]. (e) GO analyses of genes marked with both H3K4me3 and H3K27me3.

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