Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells

Figure 2

Correlation between histone marks and gene expression level and identification of bivalent genes showing derepression after differentiation induction. (a) Pearson’s correlation coefficient analysis revealed that the levels of H3K4me3 enrichment were positively correlated with gene expression levels (). By contrast, levels of H3K27me3 enrichment were inversely correlated with gene expression levels ( = -0.24). (b) Box plot showing the 25th, 50th, and 75th percentiles of expression for genes with different histone modifications. (c) Scatter diagrams of the microarray analysis. Alterations in gene expression following hepatocytic differentiation in response to OSM and cholangiocytic differentiation in response to TNF-α were analyzed via microarray-based expression analysis. The red and green lines represent the borderline for the 2-fold increases and decreases, respectively. (d) Venn diagram depicted the number of bivalent genes showing derepression after differentiation induction.

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