Mesenchymal Stem Cell-Based Therapy for Allergic Rhinitis

Table 1

Soluble factors critical for MSCs-mediated immunosuppression.

Soluble factors	Immunomodulatory effect	Reference
PGE2	Inhibiting the maturation of DCs; Inhibiting the proliferation, cytotoxicity, and cytokine production of NK cells; Suppressing CD8+ T cell-mediated activation	[19–21]
IDO	Inhibiting the proliferation, cytotoxicity, and cytokine production of NK cells; Suppressing the proliferation of T cells; Suppressing CD8+ T cell-mediated activation	[20–22]
TGF-β	Suppressing CD8+ T cell-mediated activation; Inducing Tregs	[21, 23]
IL-10	Suppressing the proliferation of T cells; Inhibiting Th17 cell differentiation	[22, 24]
NO	Suppressing the proliferation of T cells	[25]
TSG-6	Inhibiting the maturation and function of DCs	[26]
IL-6	Inhibiting the differentiation of DCs	[27]
LIF	Inhibiting the proliferation of T cells	[28]
HLA-G5	Suppressing the proliferation of T cells; Inducing the expansion of Tregs; Inhibiting the cytotoxicity and cytokine production of NK cells	[14]
IL1RA	Suppressing the differentiation of B cells	[29]