Recent Advance in Source, Property, Differentiation, and Applications of Infrapatellar Fat Pad Adipose-Derived Stem Cells

Table 3

Factors associated with osteogenic differentiation of ASCs and IPFP-ASCs.

Year	Species	Cells	Factors	Outcome	Reference
2018	Human	Sc-ASCs (epididymal fat pads)	Knocking out FAK gene	Promoting osteogenic differentiation	[69]
2018	Human	Sc-ASCs	AtECM	Reducing the activity in early osteogenesis	[70]
2017	Human	IPFP-ASCs	Coculture with fetal cartilage on polycaprolactone scaffold	Reduced type II collagen and polyproteoglycan and increased Indian hedgehog factor	[68]
2017	Human	IPFP-ASCs	RHEB overexpression in IPFP-ASCs	Promoting osteogenic differentiation	[56]
2016	Human	ASCs from Life Technology (USA)	MSCs cultured in 20%, 40%, and 60% FB scaffolds	Promoting osteogenic differentiation, and osteogenic differentiation is more obvious in 40% and 60% FB scaffolds	[71]
2016	Human	ASCs from Life Technology (USA)	Scaffolds with large stiffness and small aperture	Osteogenesis is preferential	[71]
2016	Mice	Sc-ASCs (inguinal fat pads)	The 3^rd to 12^th passage Sc-ASCs	Increased osteogenic differentiation	[6]
2016	Mice	Sc-ASCs (inguinal fat pads)	Low-density sowing	Toward osteogenic differentiation	[6]
2015	Human	Sc-ASCs	Osteogenic induction medium containing GLP-1	Promoting osteogenic differentiation	[72]
2014	Rat	Sc-ASCs (inguinal fat pad)	Medium containing rhPDGF-BB	Promoting osteogenic differentiation	[73]
2014	Human	Sc-ASCs	Amplification on BM-ECM	Producing more osteoblasts	[74]
2014	Human	Sc-ASCs	Subcutaneous implantation of MSCs induced by BM-ECM in nude mice	Producing more bone tissue	[74]
2014	Human	ASCs from Lonza (Basel, Switzerland)	Addition of fullerol	Improving osteogenic potential	[75]
2013	Mice	IPFP-ASCs	Obesity	Promoting osteogenesis	[67]
2012	Mice	Sc-ASCs	Inhibiting zfp467 gene	Stimulating osteoblast development	[76]
2012	Rat	Sc-ASCs (inguinal fat pads)	Mechanical load or maintaining static stretching	Promoting osteogenesis	[77]
2011	Human	Sc-ASCs	Noggin gene knockout	Enhancing osteogenic differentiation	[78]
2011	Human	Sc-ASCs	BMP-2	Enhancing osteogenic potential	[78]
2011	Bear	Sc-ASCs	Bone growth factor	Promoting osteogenesis	[65]
2011	Cattle	IPFP-ASCs	Multiple passages	Toward osteogenic differentiation	[7]
2010	Mice	ASCs (inguinal fat pads)	shh-N overexpression in ASCs	Promoting osteogenic differentiation	[79]
2009	Mice	Sc-ASCs (inguinal fat pads)	Inhibition of histone deacetylase activity in reduced oxygen environment	Promoting osteogenic differentiation	[80]
2008	Pig	Sc-ASCs	rhBMP-6 overexpression in Sc-ASCs	Inducing bone formation and obtaining spinal fusion	[81]
2006	Rat	Sc-ASCs (inguinal fat pads)	Runx-2 overexpression in Sc-ASCs	Enhancing osteoblastic differentiation	[82]
2003	Human	IPFP-ASCs	BMP-2 cDNA overexpression in IPFP-ASCs	Promoting osteogenesis	[1]
2002	Rat	BM-MSCs	Fluid flow	Increasing mineralized matrix deposition in a dose-dependent manner	[83]

ASCs: adipose-derived stem cells; IPFP-ASCs: infrapatellar fat pad adipose-derived stem cells; Sc-ASCs: subcutaneous adipose-derived stem cells; AtECM: adipose tissue extracellular matrix; RHEB: ras homolog enriched in brain; FB: firming buffer; GLP-1: glucagon-like peptide-1; rhPDGF-BB: recombinant human platelet-derived growth factor; BM-ECM: bone marrow-extracellular matrix; BMP-2: bone morphogenetic protein-2; shh-N: N-terminal Sonic Hedgehog; rhBMP-6: recombinant human bone morphogenetic protein-6.