Review Article

Recent Advance in Source, Property, Differentiation, and Applications of Infrapatellar Fat Pad Adipose-Derived Stem Cells

Table 4

Factors associated with adipogenic differentiation of ASCs and IPFP-ASCs.

YearSpeciesCellsFactorsOutcomeReference

2018HumanASCs from Lonza (Basel, Switzerland)Treated with ET-1Promoting adipogenic differentiation[50]
2018HumanASCs from Lonza (Basel, Switzerland)Inducing ASCs after inhibiting ET receptorPromoting adipogenic differentiation[50]
2018HumanSc-ASCsAtECMPromoting adipogenic differentiation in the first 7 days of differentiation induction[70]
2017HumanIPFP-ASCsHyaluronic acidPromoting adipogenic differentiation[52]
2017HumanIPFP-ASCsRHEB overexpression in IPFP-ASCsPromoting adipogenic differentiation[56]
2017HumanSc-ASCsAddition of 2, 5, and 10 μm of pyrinteginLipid accumulation is the most marked in 2 μm of pyrintegin[85]
2016HumanSc-ASCsmiRNA-29b overexpression in Sc-ASCsPromoting adipogenic differentiation[86]
2016HumanASCs from Life Technology (USA)ASCs cultured in 20%, 40%, and 60% FB scaffoldsPromoting adipogenic differentiation, and osteogenic differentiation is the most obvious in 20% FB scaffolds[71]
2016HumanASCs from Life Technology (USA)Scaffolds with low stiffness and large aperturePromoting adipogenic differentiation[71]
2016MiceSc-ASCs (inguinal fat pads)The 3rd to 12th passage Sc-ASCsInhibiting adipogenic differentiation[6]
2015HumanSc-ASCsAdipogenic induction medium containing GLP-1Inhibiting adipogenic differentiation[72]
2014RatSc-ASCs (inguinal fat pads)ERK inhibitor (PD98059)Promoting adipogenic differentiation[73]
2014MiceSc-ASCs (inguinal fat pads)Removing ovariesPromoting adipogenic differentiation[87]
2013MiceIPFP-ASCsObesityPromoting adipogenic differentiation[67]
2013RatSc-ASCs (inguinal fat pads)Secretory factors from rat adipose tissue explantsPromoting adipogenic differentiation[88]
2012MiceSc-ASCsInhibiting zfp467 geneInhibiting adipogenic differentiation[76]
2012PigSc-ASCsA differentiation inducer which consisted by dexamethasone, insulin, and methylxanthine and combined with myostatinInhibiting adipogenic differentiation[89]
2012RatSc-ASCs (inguinal fat pads)Mechanical cyclic loading on Sc-ASCsInhibiting adipogenic differentiation[77]
2011BearSc-ASCsAdipogenic induction mediumLipid droplet accumulation[65]
2011CattleIPFP-ASCsThe fifth passageInhibiting adipogenic differentiation[7]
2010MiceSc-ASCs (inguinal fat pads)Blocking endogenous hedgehog signaling pathway and adding hedgehog antagonistsPromoting adipogenic differentiation[79]
2009MiceASCs (inguinal fat pads)Transient exposure to histone deacetylase inhibitor under hypoxiaInhibiting adipogenic differentiation[80]
2006RatSc-ASCs (inguinal fat pads)Runx-2 overexpression in Sc-ASCsInhibiting adipogenic differentiation[82]

ASCs: adipose-derived stem cells; IPFP-ASCs: infrapatellar fat pad adipose-derived stem cells; ET-1: endothelin-1; AtECM: adipose tissue extracellular matrix; RHEB: ras homolog enriched in brain; FB: firming buffer; GLP-1: glucagon-like peptide-1; ERK: extracellular signal-related kinase.