Year Species Diseases Cells Methods Outcome Reference 2018 Human Osteoarthritis Ha-MSCs Injection of Ha-MSCs into knee joint cavity No severe side effects, relieving pain, restoring function, increasing cartilage mass [108 ] 2018 Human Osteoarthritis Sc-ASCs Injection of Sc-ASCs into knee joint cavity Reducing cartilage defects by regeneration of hyaline-like articular cartilage [109 ] 2018 Human Osteoarthritis Sc-ASCs Injection of PRG into knee joint cavity Relieving pain [11 ] 2018 Human In vitro model of meniscal tear Sc-MSCs Coculture medium of Sc-MSCs and TGF-β was added into bovine meniscus tear in vitro model Showing strong matrix-sulfated proteoglycan deposition and promoting healing [110 ] 2016 Human Osteoarthritis Sc-ASCs Injection of Sc-ASCs ( Relieving pain and restoring function, especially in [111 ] 2015 Human Bone destruction of long bone Sc-ASCs Transplantation of three-dimensional graft from autologous Sc-ASCs and decalcified bone matrix into knee joint Promoting osteogenesis in bone nonunions and restoring anatomic structure without oncological side effects [112 ] 2014 Rabbit Osteoporosis Sc-ASCs Injection of Sc-ASCs into knee joint cavity Promoting bone regeneration in vivo and relieving osteoporosis [113 ] 2014 Rat Abdominal aortic aneurysm Sc-ASCs Injection of Sc-ASCs into abdominal aortic aneurysm Promoting the expression of elastin in smooth muscle and facilitating the reconstruction of elastic membrane [114 ] 2012 Human Osteoarthritis IPFP-ASCs Injection of IPFP-ASCs into knee joint cavity Effectively relieve pain and improve the function of knee joint [99 ] 2011 Human Calvarial defects Sc-ASCs Transplantation of Sc-ASCs with Noggin knockout into the destroyed skull in mice Rapidly repairing mouse calvarial defects [78 ] 2010 Mice Tibia destruction Sc-ASCs Transplantation of ASCs stimulated by N-terminal sonic hedgehog into tibial defect Enhancing osteogenesis [79 ] 2008 Pig Lumbar disc degeneration IPFP-ASCs Injection of IPFP-ASCs with rhBMP-6 overexpression into lumbar paravertebral muscle Spinal fusion and new bone formation [81 ] 2003 Human Osteoarthritis IPFP-ASCs IPFP-ASCs were embedded into fibrin glue nodules, for inducing chondrogenic cells, and were placed in osteogenic media containing BMP-2 for inducing osteogenic cells, respectively. And then these cells were transplanted into the hind legs of nude mice Cartilage formation induced by fibrin glue nodules, bone formation induced by BMP-2, and bone marrow cavity formation in the hind legs of the osteogenic culture group [1 ]
